Endocrine Abstracts

A 26-year-old man presented with a 3-month history of polydipsia, polyuria and nocturia. Physical examination was unremarkable. Random blood glucose was 5.1 mmol/l, sodium 147 mmol/l, serum osmolality 297 mOsm/kg, urine osmolality 81 mOsm/kg. A water deprivation test confirmed cranial diabetes insipidus. Magnetic resonance imaging (MRI) of his pituitary gland revealed nodular thickening of the pituitary stalk suggestive of inflammatory or neoplastic aetiology. He also complain...

Introduction: Anti-epileptic drugs (AED) adversely affecting bone health. However, individual variations between different AEDs exist and not all AEDs are equally toxic to the bone. There is almost equipoise about the effect of valproate on bone.Methods: We conducted a cross-sectional study assessing bone mineral density with dual energy X-ray absorptiometry at the hip and lumbar spine in 33 outpatients receiving valproate for ≥1 year and 36 health...

Aims and objectives: To assess the effect of Comprehensive Yogic Breathing Program on glycemic control, quality of life, and cardiac autonomic functions in diabetes.Material and methods: This is a prospective randomized controlled intervention trial. 120 diabetes patients who were having HbA1c between 6 and 8% for atleast 6 months were selected. Oral drug dose was adjusted to keep the HbA1c between 6 and 8. Plasma fasting glucose, post prandial plasma gl...

Introduction: Metformin is now one of the most common treatments for PCOS. However controversy exists about the usefulness of metformin in PCOS women with normal insulin sensitivity and normal weight. The aim of this study was to compare efficacy of metformin treatment for the purpose of restoration of ovulation in lean and obese women with polycystic ovary syndrome.Design: Thirty-six unovulatory women with PCOS (21 lean with mean body mass index (BMI) 2...

Introduction: Anti-Müllerian hormone (AMH) has an inhibitory role during folliculogenesis, which may contribute to anovulation in polycistic ovary syndrome (PCOS). AMH level has been shown to be a predictor of reproductive response to weight loss and clomiphene citrate in women with PCOS. The aim of this study was to evaluate the role of AMH as a predictor of improvements in menstrual cyclicity and ovulation induction by metformin in lean women with PCOS.<p class="abs...

Introduction: Obese humans have increased plasma levels of endocannabinoids like anandamide (AEA) and 2-arachydonoyl-glycerol (2-AG). However, it is unknown whether these orexigenic signals have a role in human eating behavior.Design: We measured plasma AEA and 2-AG levels in 12 normal weight (10 F, age: 39.1±3.7 years, body mass index (BMI): 21.0±0.6 kg/m2, waist circumference (WC): 73.8±2.9 cm) and 12 insulin-resistant obese s...

Introduction: Carneys complex is an uncommon cause of ACTH independent cushings syndrome which occurs as a combination of myxomas, spotty pigmentation and endocrine overactivity. Primary pigmented nodular adrenocortical disease (PPNAD) is seen in 25–45% of patients with Carneys complex.Methods: Three patients who were suspected with carneys complex were studied to look if their biochemical radiological and clinical characters could predict postopera...

Parathyroidectomy is the only definitive cure for primary hyperparathyroidism (PHPT). The standard for pre-operative localisation of parathyroid pathology at our institution is both a (99m)Tc-sestamibi SPECT/CT (sestamibi) and neck ultrasound scan (USS). The aim of this audit was to assess the accuracy of this standard pre-operative imaging.Methods: Retrospective data was gathered from all parathyroidectomies performed at St Thomas’ Hospital between...

Background: No treatment guidelines exist for CAH adults. To address this we have undertaken a cross-sectional analysis of health status.Patients and methods: Three hundred and eighty patients from 17 tertiary centres were contacted: 203 (53%) consented (138 f, 65 m, median age 34 (range 18–69) years). One hundred and sixty-five had classic and 34 non-classic CAH. The UK prevalence is 3591 adults >18 years therefore the capture rate was 5.7%. Re...